Critical Molecular Determinants of α7 Nicotinic Acetylcholine Receptor Allosteric Activation: SEPARATION OF DIRECT ALLOSTERIC ACTIVATION AND POSITIVE ALLOSTERIC MODULATION

The α7 nicotinic acetylcholine receptors (nAChRs) are uniquely sensitive to selective positive allosteric modulators (PAMs), which increase the efficiency of channel activation to a level greater than that of other nAChRs. Although PAMs must work in concert with “orthosteric” agonists, compounds suc...

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Detalhes bibliográficos
Publicado no:J Biol Chem
Main Authors: Horenstein, Nicole A., Papke, Roger L., Kulkarni, Abhijit R., Chaturbhuj, Ganesh U., Stokes, Clare, Manther, Khan, Thakur, Ganesh A.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2016
Assuntos:
Molecular Biophysics
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4777841/
https://ncbi.nlm.nih.gov/pubmed/26742843
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M115.692392
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