Allosteric Agonism of α7 Nicotinic Acetylcholine Receptors: Receptor Modulation Outside the Orthosteric Site

Nicotinic acetylcholine receptors (nAChRs) are members of the Cys-loop superfamily of ligand-gated ion channels. Typically, channel activation follows the binding of agonists to the orthosteric binding sites of the receptor. α7 nAChRs have a very low probability of channel activation, which can be r...

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Detalhes bibliográficos
Publicado no:Mol Pharmacol
Main Authors: Gulsevin, Alican, Papke, Roger L., Stokes, Clare, Garai, Sumanta, Thakur, Ganesh A., Quadri, Marta, Horenstein, Nicole A.
Formato: Artigo
Idioma:Inglês
Publicado em: The American Society for Pharmacology and Experimental Therapeutics 2019
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Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6491904/
https://ncbi.nlm.nih.gov/pubmed/30944209
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/mol.119.115758
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