Heteromeric Neuronal Nicotinic Acetylcholine Receptors with Mutant β Subunits Acquire Sensitivity to α7-Selective Positive Allosteric Modulators

Homomeric α7 nicotinic acetylcholine receptors (nAChR) have an intrinsically low probability of opening that can be overcome by α7-selective positive allosteric modulators (PAMs), which bind at a site involving the second transmembrane domain (TM2). Mutation of a methionine that is unique to α7 at t...

Full beskrivning

Sparad:
Bibliografiska uppgifter
I publikationen:J Pharmacol Exp Ther
Huvudupphovsmän: Stokes, Clare, Garai, Sumanta, Kulkarni, Abhijit R., Cantwell, Lucas N., Noviello, Colleen M., Hibbs, Ryan E., Horenstein, Nicole A., Abboud, Khalil A., Thakur, Ganesh A., Papke, Roger L.
Materialtyp: Artigo
Språk:Inglês
Publicerad: The American Society for Pharmacology and Experimental Therapeutics 2019
Ämnen:
Neuropharmacology
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC6658922/
https://ncbi.nlm.nih.gov/pubmed/31175218
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/jpet.119.259499
Taggar: Lägg till en tagg
Inga taggar, Lägg till första taggen!

Liknande verk