Anti-inflammatory Silent Agonists

gan Horenstein, Nicole A., Papke, Roger L.
Cyhoeddwyd yn ACS Med Chem Lett (2017)

Therapeutic Targeting of α7 Nicotinic Acetylcholine Receptors

gan Papke, Roger L., Horenstein, Nicole A.
Cyhoeddwyd yn Pharmacol Rev (2021)

A Computational Analysis of the Factors Governing the Dynamics of α7 nAChR and Its Homologs

gan Gulsevin, Alican, Meiler, Jens, Horenstein, Nicole A.
Cyhoeddwyd yn Biophys J (2020)

Synthesis of H-bonding probes of α7 nAChR agonist selectivity

gan Wang, Jingyi, Papke, Roger L., Horenstein, Nicole A.
Cyhoeddwyd 2008

Synthesis and evaluation of a conditionally-silent agonist for the α7 nicotinic acetylcholine receptor

gan Chojnacka, Kinga, Papke, Roger L., Horenstein, Nicole A.
Cyhoeddwyd 2013

The Minimal Pharmacophore for Silent Agonism of the α(7) Nicotinic Acetylcholine Receptor

gan Papke, Roger L., Chojnacka, Kinga, Horenstein, Nicole A.
Cyhoeddwyd 2014

Nicotinic Activity of Arecoline, the Psychoactive Element of "Betel Nuts", Suggests a Basis for Habitual Use and Anti-Inflammatory Activity

gan Papke, Roger L., Horenstein, Nicole A., Stokes, Clare
Cyhoeddwyd yn PLoS One (2015)

Dissection of N,N-diethyl-N′-phenylpiperazines as α7 nicotinic receptor silent agonists

gan Quadri, Marta, Papke, Roger L., Horenstein, Nicole A.
Cyhoeddwyd yn Bioorg Med Chem (2015)

Multiple Pharmacophores for the Selective Activation of Nicotinic α7-Type Acetylcholine Receptors

gan Horenstein, Nicole A., Leonik, Fedra M., Papke, Roger L.
Cyhoeddwyd 2008

A Free Energy Study of the Catalytic Mechanism of Trypanosoma cruzi Trans-Sialidase. From the Michaelis Complex to the Covalent Intermediate()

gan Pierdominici-Sottile, Gustavo, Horenstein, Nicole A., Roitberg, Adrian E.
Cyhoeddwyd 2011

Tethered Agonist Analogs as Site-Specific Probes for Domains of the Human α7 Nicotinic Acetylcholine Receptor that Differentially Regulate Activation and Desensitization

gan Wang, Jingyi, Horenstein, Nicole A., Stokes, Clare, Papke, Roger L.
Cyhoeddwyd 2010

Potential State-selective Hydrogen Bond Formation Can Modulate Activation and Desensitization of the α7 Nicotinic Acetylcholine Receptor

gan Wang, Jingyi, Papke, Roger L., Stokes, Clare, Horenstein, Nicole A.
Cyhoeddwyd 2012

Differential Regulation of Receptor Activation and Agonist Selectivity by Highly Conserved Tryptophans in the Nicotinic Acetylcholine Receptor Binding Site

gan Williams, Dustin K., Stokes, Clare, Horenstein, Nicole A., Papke, Roger L.
Cyhoeddwyd 2009

The effective opening of nicotinic acetylcholine receptors with single agonist binding sites

gan Williams, Dustin K., Stokes, Clare, Horenstein, Nicole A., Papke, Roger L.
Cyhoeddwyd 2011

Cysteine accessibility analysis of the human alpha7 nicotinic acetylcholine receptor ligand-binding domain identifies L119 as a gatekeeper

gan Papke, Roger L., Stokes, Clare, Williams, Dustin, Wang, Jingyi, Horenstein, Nicole A.
Cyhoeddwyd 2010

Cracking the Betel Nut: Cholinergic Activity of Areca Alkaloids and Related Compounds

gan Horenstein, Nicole A, Quadri, Marta, Stokes, Clare, Shoaib, Mohammed, Papke, Roger L
Cyhoeddwyd yn Nicotine Tob Res (2017)

Synthesis of saccharin-glycoconjugates targeting carbonic anhydrase using a one-pot cyclization/deprotection strategy.

gan Murray, Akilah B., Quadri, Marta, Li, Haoxi, McKenna, Robert, Horenstein, Nicole A.
Cyhoeddwyd yn Carbohydr Res (2019)

The characterization of a novel rigid nicotine analog with α7-selective nAChR agonist activity and modulation of agonist properties by boron inclusion

gan Papke, Roger L., Zheng, Guangrong, Horenstein, Nicole A., Dwoskin, Linda P., Crooks, Peter A.
Cyhoeddwyd 2005

Point-to-point ligand-receptor interactions across the subunit interface modulate the induction and stabilization of conformational states of alpha7 nAChR by benzylidene anabaseine...

gan Isaacson, Matthew D., Horenstein, Nicole A., Stokes, Clare, Kem, William R., Papke, Roger L.
Cyhoeddwyd 2013

Activation and Desensitization of Nicotinic α7-type Acetylcholine Receptors by Benzylidene Anabaseines and Nicotine

gan Papke, Roger L., Kem, William R., Soti, Ferenc, López-Hernández, Gretchen Y., Horenstein, Nicole A.
Cyhoeddwyd 2009