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The characterization of a novel rigid nicotine analog with α7-selective nAChR agonist activity and modulation of agonist properties by boron inclusion

The α7 nAChR subtype is of particular interest as a potential therapeutic target since it has been implicated as a mediator of both cognitive and neuroprotective activity. The rigid nicotine analog ACME and the N-cyanoborane conjugate ACME-B are selective partial agonists of rat α7 receptors express...

Πλήρης περιγραφή

Αποθηκεύτηκε σε:
Λεπτομέρειες βιβλιογραφικής εγγραφής
Κύριοι συγγραφείς: Papke, Roger L., Zheng, Guangrong, Horenstein, Nicole A., Dwoskin, Linda P., Crooks, Peter A.
Μορφή: Artigo
Γλώσσα:Inglês
Έκδοση: 2005
Θέματα:
Διαθέσιμο Online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3593044/
https://ncbi.nlm.nih.gov/pubmed/16005216
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2005.05.118
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