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The effective opening of nicotinic acetylcholine receptors with single agonist binding sites

We have identified a means by which agonist-evoked responses of nicotinic receptors can be conditionally eliminated. Modification of α7L119C mutants by the sulfhydryl reagent 2-aminoethyl methanethiosulfonate (MTSEA) reduces responses to acetylcholine (ACh) by more than 97%, whereas corresponding mu...

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Detalhes bibliográficos
Main Authors: Williams, Dustin K., Stokes, Clare, Horenstein, Nicole A., Papke, Roger L.
Formato: Artigo
Idioma:Inglês
Publicado em: The Rockefeller University Press 2011
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3068282/
https://ncbi.nlm.nih.gov/pubmed/21444659
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1085/jgp.201010587
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