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The effective opening of nicotinic acetylcholine receptors with single agonist binding sites
We have identified a means by which agonist-evoked responses of nicotinic receptors can be conditionally eliminated. Modification of α7L119C mutants by the sulfhydryl reagent 2-aminoethyl methanethiosulfonate (MTSEA) reduces responses to acetylcholine (ACh) by more than 97%, whereas corresponding mu...
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| Main Authors: | , , , |
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| Format: | Artigo |
| Language: | Inglês |
| Published: |
The Rockefeller University Press
2011
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| Subjects: | |
| Online Access: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3068282/ https://ncbi.nlm.nih.gov/pubmed/21444659 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1085/jgp.201010587 |
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