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The Minimal Pharmacophore for Silent Agonism of the α(7) Nicotinic Acetylcholine Receptor
The minimum pharmacophore for activation of the human α(7) nicotinic acetylcholine receptor (nAChR) is the tetramethylammonium cation. Previous work demonstrated that larger quaternary ammonium compounds, such as diethyldimethylammonium or 1-methyl quinuclidine, were α(7)-selective partial agonists,...
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| Main Authors: | , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
The American Society for Pharmacology and Experimental Therapeutics
2014
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4152879/ https://ncbi.nlm.nih.gov/pubmed/24990939 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/jpet.114.215236 |
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