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The Minimal Pharmacophore for Silent Agonism of the α(7) Nicotinic Acetylcholine Receptor
The minimum pharmacophore for activation of the human α(7) nicotinic acetylcholine receptor (nAChR) is the tetramethylammonium cation. Previous work demonstrated that larger quaternary ammonium compounds, such as diethyldimethylammonium or 1-methyl quinuclidine, were α(7)-selective partial agonists,...
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| Asıl Yazarlar: | , , |
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| Materyal Türü: | Artigo |
| Dil: | Inglês |
| Baskı/Yayın Bilgisi: |
The American Society for Pharmacology and Experimental Therapeutics
2014
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| Konular: | |
| Online Erişim: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4152879/ https://ncbi.nlm.nih.gov/pubmed/24990939 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/jpet.114.215236 |
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