Potential State-selective Hydrogen Bond Formation Can Modulate Activation and Desensitization of the α7 Nicotinic Acetylcholine Receptor

A series of arylidene anabaseines were synthesized to probe the functional impact of hydrogen bonding on human α7 nicotinic acetylcholine receptor (nAChR) activation and desensitization. The aryl groups were either hydrogen bond acceptors (furans), donors (pyrroles), or neither (thiophenes). These c...

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Detaylı Bibliyografya
Asıl Yazarlar: Wang, Jingyi, Papke, Roger L., Stokes, Clare, Horenstein, Nicole A.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: American Society for Biochemistry and Molecular Biology 2012
Konular:
Molecular Biophysics
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC3381156/
https://ncbi.nlm.nih.gov/pubmed/22556416
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.339796
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