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Potential State-selective Hydrogen Bond Formation Can Modulate Activation and Desensitization of the α7 Nicotinic Acetylcholine Receptor

A series of arylidene anabaseines were synthesized to probe the functional impact of hydrogen bonding on human α7 nicotinic acetylcholine receptor (nAChR) activation and desensitization. The aryl groups were either hydrogen bond acceptors (furans), donors (pyrroles), or neither (thiophenes). These c...

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Autori principali: Wang, Jingyi, Papke, Roger L., Stokes, Clare, Horenstein, Nicole A.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Biochemistry and Molecular Biology 2012
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3381156/
https://ncbi.nlm.nih.gov/pubmed/22556416
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.339796
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