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Sulfonium as a surrogate for Ammonium: A new α7 nicotinic acetylcholine receptor partial agonist with desensitizing activity
Weak partial agonists that promote a desensitized state of the α7 nicotinic acetylcholine receptor (nAChR) have been associated with anti-inflammatory effects. Exemplar compounds feature a tertiary or quaternary ammonium group. We report the synthesis, structure, and electrophysiological evaluation...
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| Publicado no: | J Med Chem |
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| Main Authors: | , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2017
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5653211/ https://ncbi.nlm.nih.gov/pubmed/28885019 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.jmedchem.7b00875 |
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