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Sulfonium as a surrogate for Ammonium: A new α7 nicotinic acetylcholine receptor partial agonist with desensitizing activity

Weak partial agonists that promote a desensitized state of the α7 nicotinic acetylcholine receptor (nAChR) have been associated with anti-inflammatory effects. Exemplar compounds feature a tertiary or quaternary ammonium group. We report the synthesis, structure, and electrophysiological evaluation...

पूर्ण विवरण

में बचाया:
ग्रंथसूची विवरण
में प्रकाशित:J Med Chem
मुख्य लेखकों: Quadri, Marta, Stokes, Clare, Gulsevin, Alican, Felts, Ashley C. J., Abboud, Khalil A., Papke, Roger L., Horenstein, Nicole A.
स्वरूप: Artigo
भाषा:Inglês
प्रकाशित: 2017
विषय:
ऑनलाइन पहुंच:https://ncbi.nlm.nih.gov/pmc/articles/PMC5653211/
https://ncbi.nlm.nih.gov/pubmed/28885019
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.jmedchem.7b00875
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