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Allosterically Potentiated α7 Nicotinic Acetylcholine Receptors: Reduced Calcium Permeability and Current-Independent Control of Intracellular Calcium

The currents of α7 nicotinic acetylcholine receptors activated by acetylcholine (ACh) are brief. The channel has high permeability to calcium relative to monovalent cations and shows inward rectification. It has been previously noted that in the presence of positive allosteric modulators (PAMs), cur...

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Detalhes bibliográficos
Publicado no:Mol Pharmacol
Main Authors: Miller, Douglas R., Khoshbouei, Habibeh, Garai, Sumanta, Cantwell, Lucas N., Stokes, Clare, Thakur, Ganesh, Papke, Roger L.
Formato: Artigo
Idioma:Inglês
Publicado em: The American Society for Pharmacology and Experimental Therapeutics 2020
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7662531/
https://ncbi.nlm.nih.gov/pubmed/33020143
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/molpharm.120.000012
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