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Persistent activation of α7 nicotinic ACh receptors associated with stable induction of different desensitized states
BACKGROUND AND PURPOSE: GAT107 ((3aR,4S,9bS)‐4‐(4‐bromo‐phenyl)‐3a,4,5,9b‐tetrahydro‐3H‐cyclopenta‐[c]quinoline‐8‐sulfonamide) is a positive allosteric modulator (PAM) and agonist of α7 nicotinic acetylcholine receptors (nAChRs)that can cause a prolonged period of primed potentiation of acetylcholin...
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| Publicat a: | Br J Pharmacol |
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| Autors principals: | , , , , , , , , |
| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
John Wiley and Sons Inc.
2017
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5979752/ https://ncbi.nlm.nih.gov/pubmed/28477386 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bph.13851 |
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