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Persistent activation of α7 nicotinic ACh receptors associated with stable induction of different desensitized states

BACKGROUND AND PURPOSE: GAT107 ((3aR,4S,9bS)‐4‐(4‐bromo‐phenyl)‐3a,4,5,9b‐tetrahydro‐3H‐cyclopenta‐[c]quinoline‐8‐sulfonamide) is a positive allosteric modulator (PAM) and agonist of α7 nicotinic acetylcholine receptors (nAChRs)that can cause a prolonged period of primed potentiation of acetylcholin...

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書目詳細資料
發表在:Br J Pharmacol
Main Authors: Papke, Roger L, Stokes, Clare, Damaj, M Imad, Thakur, Ganesh A, Manther, Khan, Treinin, Millet, Bagdas, Deniz, Kulkarni, Abhijit R, Horenstein, Nicole A
格式: Artigo
語言:Inglês
出版: John Wiley and Sons Inc. 2017
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC5979752/
https://ncbi.nlm.nih.gov/pubmed/28477386
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bph.13851
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