Persistent activation of α7 nicotinic ACh receptors associated with stable induction of different desensitized states

BACKGROUND AND PURPOSE: GAT107 ((3aR,4S,9bS)‐4‐(4‐bromo‐phenyl)‐3a,4,5,9b‐tetrahydro‐3H‐cyclopenta‐[c]quinoline‐8‐sulfonamide) is a positive allosteric modulator (PAM) and agonist of α7 nicotinic acetylcholine receptors (nAChRs)that can cause a prolonged period of primed potentiation of acetylcholin...

Descripción completa

Guardado en:
Detalles Bibliográficos
Publicado en:Br J Pharmacol
Autores principales: Papke, Roger L, Stokes, Clare, Damaj, M Imad, Thakur, Ganesh A, Manther, Khan, Treinin, Millet, Bagdas, Deniz, Kulkarni, Abhijit R, Horenstein, Nicole A
Formato: Artigo
Lenguaje:Inglês
Publicado: John Wiley and Sons Inc. 2017
Materias:
Themed Section: Research Papers
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC5979752/
https://ncbi.nlm.nih.gov/pubmed/28477386
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bph.13851
Etiquetas: Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!

Ejemplares similares