Design of New α-Conotoxins: From Computer Modeling to Synthesis of Potent Cholinergic Compounds

Por Kasheverov, Igor E., Zhmak, Maxim N., Khruschov, Alexey Y., Tsetlin, Victor I.
Publicado em 2011

6-Bromohypaphorine from Marine Nudibranch Mollusk Hermissenda crassicornis is an Agonist of Human α7 Nicotinic Acetylcholine Receptor

Por Kasheverov, Igor E., Shelukhina, Irina V., Kudryavtsev, Denis S., Makarieva, Tatyana N., Spirova, Ekaterina N., Guzii, Alla G., Stonik, Valentin A., Tsetlin, Victor I.
Publicado no Mar Drugs (2015)

From crystal structure of α-conotoxin GIC in complex with Ac-AChBP to molecular determinants of its high selectivity for α3β2 nAChR

Por Lin, Bo, Xu, Manyu, Zhu, Xiaopeng, Wu, Yong, Liu, Xi, Zhangsun, Dongting, Hu, Yuanyan, Xiang, Shi-Hua, Kasheverov, Igor E., Tsetlin, Victor I., Wang, Xinquan, Luo, Sulan
Publicado no Sci Rep (2016)

Dimeric α-Cobratoxin X-ray Structure: LOCALIZATION OF INTERMOLECULAR DISULFIDES AND POSSIBLE MODE OF BINDING TO NICOTINIC ACETYLCHOLINE RECEPTORS

Por Osipov, Alexey V., Rucktooa, Prakash, Kasheverov, Igor E., Filkin, Sergey Yu., Starkov, Vladislav G., Andreeva, Tatyana V., Sixma, Titia K., Bertrand, Daniel, Utkin, Yuri N., Tsetlin, Victor I.
Publicado em 2012

Inhibition of Nicotinic Acetylcholine Receptors, a Novel Facet in the Pleiotropic Activities of Snake Venom Phospholipases A(2)

Por Vulfius, Catherine A., Kasheverov, Igor E., Starkov, Vladislav G., Osipov, Alexey V., Andreeva, Tatyana V., Filkin, Sergey Yu., Gorbacheva, Elena V., Astashev, Maxim E., Tsetlin, Victor I., Utkin, Yuri N.
Publicado no PLoS One (2014)

High-Affinity α-Conotoxin PnIA Analogs Designed on the Basis of the Protein Surface Topography Method

Por Kasheverov, Igor E., Chugunov, Anton O., Kudryavtsev, Denis S., Ivanov, Igor A., Zhmak, Maxim N., Shelukhina, Irina V., Spirova, Ekaterina N., Tabakmakher, Valentin M., Zelepuga, Elena A., Efremov, Roman G., Tsetlin, Victor I.
Publicado no Sci Rep (2016)

Azemiopsin from Azemiops feae Viper Venom, a Novel Polypeptide Ligand of Nicotinic Acetylcholine Receptor

Por Utkin, Yuri N., Weise, Christoph, Kasheverov, Igor E., Andreeva, Tatyana V., Kryukova, Elena V., Zhmak, Maxim N., Starkov, Vladislav G., Hoang, Ngoc Anh, Bertrand, Daniel, Ramerstorfer, Joachim, Sieghart, Werner, Thompson, Andrew J., Lummis, Sarah C. R., Tsetlin, Victor I.
Publicado em 2012

Human Secreted Ly-6/uPAR Related Protein-1 (SLURP-1) Is a Selective Allosteric Antagonist of α7 Nicotinic Acetylcholine Receptor

Por Lyukmanova, Ekaterina N., Shulepko, Mikhail A., Kudryavtsev, Denis, Bychkov, Maxim L., Kulbatskii, Dmitrii S., Kasheverov, Igor E., Astapova, Maria V., Feofanov, Alexey V., Thomsen, Morten S., Mikkelsen, Jens D., Shenkarev, Zakhar O., Tsetlin, Victor I., Dolgikh, Dmitry A., Kirpichnikov, Mikhail P.
Publicado no PLoS One (2016)

NMR Structure and Action on Nicotinic Acetylcholine Receptors of Water-soluble Domain of Human LYNX1

Por Lyukmanova, Ekaterina N., Shenkarev, Zakhar O., Shulepko, Mikhail A., Mineev, Konstantin S., D'Hoedt, Dieter, Kasheverov, Igor E., Filkin, Sergey Yu., Krivolapova, Alexandra P., Janickova, Helena, Dolezal, Vladimir, Dolgikh, Dmitry A., Arseniev, Alexander S., Bertrand, Daniel, Tsetlin, Victor I., Kirpichnikov, Mikhail P.
Publicado em 2011

Water-soluble LYNX1 Residues Important for Interaction with Muscle-type and/or Neuronal Nicotinic Receptors

Por Lyukmanova, Ekaterina N., Shulepko, Mikhail A., Buldakova, Svetlana L., Kasheverov, Igor E., Shenkarev, Zakhar O., Reshetnikov, Roman V., Filkin, Sergey Y., Kudryavtsev, Denis S., Ojomoko, Lucy O., Kryukova, Elena V., Dolgikh, Dmitry A., Kirpichnikov, Mikhail P., Bregestovski, Piotr D., Tsetlin, Victor I.
Publicado em 2013

Neurotoxins from Snake Venoms and α-Conotoxin ImI Inhibit Functionally Active Ionotropic γ-Aminobutyric Acid (GABA) Receptors

Por Kudryavtsev, Denis S., Shelukhina, Irina V., Son, Lina V., Ojomoko, Lucy O., Kryukova, Elena V., Lyukmanova, Ekaterina N., Zhmak, Maxim N., Dolgikh, Dmitry A., Ivanov, Igor A., Kasheverov, Igor E., Starkov, Vladislav G., Ramerstorfer, Joachim, Sieghart, Werner, Tsetlin, Victor I., Utkin, Yuri N.
Publicado no J Biol Chem (2015)

Marine compound rhizochalinin shows high in vitro and in vivo efficacy in castration resistant prostate cancer

Por Dyshlovoy, Sergey A., Otte, Katharina, Alsdorf, Winfried H., Hauschild, Jessica, Lange, Tobias, Venz, Simone, Bauer, Christiane K., Bähring, Robert, Amann, Kerstin, Mandanchi, Ramin, Schumacher, Udo, Schröder-Schwarz, Jennifer, Makarieva, Tatyana N., Guzii, Alla G., Tabakmakher, Kseniya M., Fedorov, Sergey N., Shubina, Larisa K., Kasheverov, Igor E., Ehmke, Heimo, Steuber, Thomas, Stonik, Valentin A., Bokemeyer, Carsten, Honecker, Friedemann, von Amsberg, Gunhild
Publicado no Oncotarget (2016)