Human Secreted Ly-6/uPAR Related Protein-1 (SLURP-1) Is a Selective Allosteric Antagonist of α7 Nicotinic Acetylcholine Receptor

SLURP-1 is a secreted toxin-like Ly-6/uPAR protein found in epithelium, sensory neurons and immune cells. Point mutations in the slurp-1 gene cause the autosomal inflammation skin disease Mal de Meleda. SLURP-1 is considered an autocrine/paracrine hormone that regulates growth and differentiation of...

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Dades bibliogràfiques
Publicat a:PLoS One
Autors principals: Lyukmanova, Ekaterina N., Shulepko, Mikhail A., Kudryavtsev, Denis, Bychkov, Maxim L., Kulbatskii, Dmitrii S., Kasheverov, Igor E., Astapova, Maria V., Feofanov, Alexey V., Thomsen, Morten S., Mikkelsen, Jens D., Shenkarev, Zakhar O., Tsetlin, Victor I., Dolgikh, Dmitry A., Kirpichnikov, Mikhail P.
Format: Artigo
Idioma:Inglês
Publicat: Public Library of Science 2016
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4764493/
https://ncbi.nlm.nih.gov/pubmed/26905431
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0149733
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