Orthosteric and/or Allosteric Binding of α-Conotoxins to Nicotinic Acetylcholine Receptors and Their Models

α-Conotoxins from Conus snails are capable of distinguishing muscle and neuronal nicotinic acetylcholine receptors (nAChRs). α-Conotoxin RgIA and αO-conotoxin GeXIVA, blocking neuronal α9α10 nAChR, are potential analgesics. Typically, α-conotoxins bind to the orthosteric sites for agonists/competiti...

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Detalhes bibliográficos
Publicado no:Mar Drugs
Main Authors: Kryukova, Elena V., Ivanov, Igor A., Lebedev, Dmitry S., Spirova, Ekaterina N., Egorova, Natalia S., Zouridakis, Marios, Kasheverov, Igor E., Tzartos, Socrates J., Tsetlin, Victor I.
Formato: Artigo
Idioma:Inglês
Publicado em: MDPI 2018
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6315749/
https://ncbi.nlm.nih.gov/pubmed/30469507
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/md16120460
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