Crystal Structure of the Monomeric Extracellular Domain of α9 Nicotinic Receptor Subunit in Complex With α-Conotoxin RgIA: Molecular Dynamics Insights Into RgIA Binding to α9α10 Nicotinic Receptors

The α9 subunit of nicotinic acetylcholine receptors (nAChRs) exists mainly in heteropentameric assemblies with α10. Accumulating data indicate the presence of three different binding sites in α9α10 nAChRs: the α9(+)/α9(−), the α9(+)/α10(−), and the α10(+)/α9(−). The major role of the principal (+) s...

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Main Authors: Marios Zouridakis, Athanasios Papakyriakou, Igor A. Ivanov, Igor E. Kasheverov, Victor Tsetlin, Socrates Tzartos, Petros Giastas
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2019-05-01
Colecção:Frontiers in Pharmacology
Assuntos:
nicotinic acetylcholine receptors
α-conotoxins
RgIA
structure
molecular modeling
molecular dynamics
Acesso em linha:https://www.frontiersin.org/article/10.3389/fphar.2019.00474/full
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