Structural Insight into Specificity of Interactions between Nonconventional Three-finger Weak Toxin from Naja kaouthia (WTX) and Muscarinic Acetylcholine Receptors

Weak toxin from Naja kaouthia (WTX) belongs to the group of nonconventional “three-finger” snake neurotoxins. It irreversibly inhibits nicotinic acetylcholine receptors and allosterically interacts with muscarinic acetylcholine receptors (mAChRs). Using site-directed mutagenesis, NMR spectroscopy, a...

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Detalhes bibliográficos
Publicado no:J Biol Chem
Main Authors: Lyukmanova, Ekaterina N., Shenkarev, Zakhar O., Shulepko, Mikhail A., Paramonov, Alexander S., Chugunov, Anton O., Janickova, Helena, Dolejsi, Eva, Dolezal, Vladimir, Utkin, Yuri N., Tsetlin, Victor I., Arseniev, Alexander S., Efremov, Roman G., Dolgikh, Dmitry A., Kirpichnikov, Mikhail P.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2015
Assuntos:
Neurobiology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4583006/
https://ncbi.nlm.nih.gov/pubmed/26242733
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M115.656595
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