Backbone cyclization of analgesic conotoxin GeXIVA facilitates direct folding of the ribbon isomer

Conotoxin GeXIVA inhibits the α9α10 nicotinic acetylcholine receptor (nAChR) and is analgesic in animal models of pain. α-Conotoxins have four cysteines that can have three possible disulfide connectivities: globular (Cys(I)–Cys(III) and Cys(II)–Cys(IV)), ribbon (Cys(I)–Cys(IV) and Cys(II)–Cys(III))...

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Detalhes bibliográficos
Publicado no:J Biol Chem
Main Authors: Wu, Xiaosa, Huang, Yen-Hua, Kaas, Quentin, Harvey, Peta J., Wang, Conan K., Tae, Han-Shen, Adams, David J., Craik, David J.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2017
Assuntos:
Protein Structure and Folding
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5641895/
https://ncbi.nlm.nih.gov/pubmed/28851841
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M117.808386
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