Cloning, synthesis, and characterization of αO-conotoxin GeXIVA, a potent α9α10 nicotinic acetylcholine receptor antagonist

We identified a previously unidentified conotoxin gene from Conus generalis whose precursor signal sequence has high similarity to the O1-gene conotoxin superfamily. The predicted mature peptide, αO-conotoxin GeXIVA (GeXIVA), has four Cys residues, and its three disulfide isomers were synthesized. P...

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保存先:
書誌詳細
出版年:Proc Natl Acad Sci U S A
主要な著者: Luo, Sulan, Zhangsun, Dongting, Harvey, Peta J., Kaas, Quentin, Wu, Yong, Zhu, Xiaopeng, Hu, Yuanyan, Li, Xiaodan, Tsetlin, Victor I., Christensen, Sean, Romero, Haylie K., McIntyre, Melissa, Dowell, Cheryl, Baxter, James C., Elmslie, Keith S., Craik, David J., McIntosh, J. Michael
フォーマット: Artigo
言語:Inglês
出版事項: National Academy of Sciences 2015
主題:
PNAS Plus
オンライン･アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC4522777/
https://ncbi.nlm.nih.gov/pubmed/26170295
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1503617112
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