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Investigating the Role of Loop C Hydrophilic Residue ‘T244’ in the Binding Site of ρ1 GABA(C) Receptors via Site Mutation and Partial Agonism

The loop C hydrophilic residue, threonine 244 lines the orthosteric binding site of ρ1 GABA(C) receptors was studied by point mutation into serine, alanine and cysteine, and tested with GABA, some representative partial agonists and antagonists. Thr244 has a hydroxyl group essential for GABA activit...

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Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: Naffaa, Moawiah M., Absalom, Nathan, Solomon, V. Raja, Chebib, Mary, Hibbs, David E., Hanrahan, Jane R.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2016
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4887073/
https://ncbi.nlm.nih.gov/pubmed/27244450
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0156618
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