Differentiating Enantioselective Actions of GABOB: A Possible Role for Threonine 244 in the Binding Site of GABA(C) ρ(1) Receptors

[Image: see text] Designing potent and subtype-selective ligands with therapeutic value requires knowledge about how endogenous ligands interact with their binding site. 4-Amino-3-hydroxybutanoic acid (GABOB) is an endogenous ligand found in the central nervous system in mammals. It is a metabolic p...

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Main Authors: Yamamoto, Izumi, Absalom, Nathan, Carland, Jane E., Doddareddy, Munikumar R., Gavande, Navnath, Johnston, Graham A. R., Hanrahan, Jane R., Chebib, Mary
Formato: Artigo
Idioma:Inglês
Publicado em: American Chemical Society 2012
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3447397/
https://ncbi.nlm.nih.gov/pubmed/23019493
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/cn3000229
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