Investigating the Role of Loop C Hydrophilic Residue ‘T244’ in the Binding Site of ρ1 GABA(C) Receptors via Site Mutation and Partial Agonism

The loop C hydrophilic residue, threonine 244 lines the orthosteric binding site of ρ1 GABA(C) receptors was studied by point mutation into serine, alanine and cysteine, and tested with GABA, some representative partial agonists and antagonists. Thr244 has a hydroxyl group essential for GABA activit...

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Udgivet i:PLoS One
Main Authors: Naffaa, Moawiah M., Absalom, Nathan, Solomon, V. Raja, Chebib, Mary, Hibbs, David E., Hanrahan, Jane R.
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2016
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4887073/
https://ncbi.nlm.nih.gov/pubmed/27244450
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0156618
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