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Investigating the Role of Loop C Hydrophilic Residue ‘T244’ in the Binding Site of ρ1 GABA(C) Receptors via Site Mutation and Partial Agonism
The loop C hydrophilic residue, threonine 244 lines the orthosteric binding site of ρ1 GABA(C) receptors was studied by point mutation into serine, alanine and cysteine, and tested with GABA, some representative partial agonists and antagonists. Thr244 has a hydroxyl group essential for GABA activit...
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| Veröffentlicht in: | PLoS One |
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| Hauptverfasser: | , , , , , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
Public Library of Science
2016
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4887073/ https://ncbi.nlm.nih.gov/pubmed/27244450 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0156618 |
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