Promoter methylation and age-related downregulation of Klotho in rhesus monkey

Por King, Gwendalyn D., Rosene, Douglas L., Abraham, Carmela R.
Publicado em 2011

Candidate molecular pathways of white matter vulnerability in the brain of normal aging rhesus monkeys

Por Robinson, Amy A., Abraham, Carmela R., Rosene, Douglas L.
Publicado no GeroScience (2018)

MicroRNA-339 and microRNA-556 regulate Klotho expression in vitro

Por Mehi, Stephen J., Maltare, Astha, Abraham, Carmela R., King, Gwendalyn D.
Publicado em 2013

A method to specifically activate the Klotho promoter by using zinc finger proteins constructed from modular building blocks and from naturally engineered Egr1 transcription factor...

Por Chen, Ci-Di, Rudy, Melissa A., Zeldich, Ella, Abraham, Carmela R.
Publicado no FASEB J (2020)

Comparable dimerization found in wildtype and familial Alzheimer’s disease amyloid precursor protein mutants

Por So, Pauline PL, Khodr, Christina E, Chen, Ci-Di, Abraham, Carmela R
Publicado em 2013

Activation of the anti-aging and cognition-enhancing gene Klotho by CRISPR-dCas9 transcriptional effector complex

Por Chen, Ci-Di, Zeldich, Ella, Li, Yuexuan, Yuste, Andrea, Abraham, Carmela R.
Publicado no J Mol Neurosci (2018)

Insulin stimulates the cleavage and release of the extracellular domain of Klotho by ADAM10 and ADAM17

Por Chen, Ci-Di, Podvin, Sonia, Gillespie, Earl, Leeman, Susan E., Abraham, Carmela R.
Publicado em 2007

Biochemical and Functional Characterization of the Klotho-VS Polymorphism Implicated in Aging and Disease Risk

Por Tucker Zhou, Tracey B., King, Gwendalyn D., Chen, CiDi, Abraham, Carmela R.
Publicado em 2013

Small-molecule Klotho enhancers as novel treatment of neurodegeneration

Por Abraham, Carmela R, Chen, CiDi, Cuny, Gregory D, Glicksman, Marcie A, Zeldich, Ella
Publicado em 2012

The Anti-Aging and Tumor Suppressor Protein Klotho Enhances Differentiation of a Human Oligodendrocytic Hybrid Cell Line

Por Chen, Ci-Di, Li, Hu, Liang, Jennifer, Hixson, Kathryn, Zeldich, Ella, Abraham, Carmela R.
Publicado no J Mol Neurosci (2014)

Acyl peptide hydrolase degrades monomeric and oligomeric amyloid-beta peptide

Por Yamin, Rina, Zhao, Cheng, O'Connor, Peter B, McKee, Ann C, Abraham, Carmela R
Publicado em 2009

Astroglial Expression of Human α(1)-Antichymotrypsin Enhances Alzheimer-like Pathology in Amyloid Protein Precursor Transgenic Mice

Por Mucke, Lennart, Yu, Gui-Qiu, McConlogue, Lisa, Rockenstein, Edward M., Abraham, Carmela R., Masliah, Eliezer
Publicado em 2000

Age-related molecular reorganization at the node of Ranvier

Por Hinman, Jason D., Peters, Alan, Cabral, Howard, Rosene, Douglas L., Hollander, William, Rasband, Matthew N., Abraham, Carmela R.
Publicado no J Comp Neurol (2006)

Serum paraoxonase activity is associated with variants in the PON gene cluster and risk of Alzheimer disease

Por Erlich, Porat M., Lunetta, Kathryn L., Cupples, L. Adrienne, Abraham, Carmela R., Green, Robert C., Baldwin, Clinton T., Farrer, Lindsay A.
Publicado em 2010

Identification of Cleavage Sites Leading to the Shed Form of the Anti-Aging Protein Klotho

Por Chen, Ci-Di, Tung, Tze Yu, Liang, Jennifer, Zeldich, Ella, Tucker Zhou, Tracey B., Turk, Benjamin E., Abraham, Carmela R.
Publicado em 2014

Identification of the cleavage sites leading to the shed forms of human and mouse anti-aging and cognition-enhancing protein Klotho

Por Chen, Ci-Di, Li, Yuexuan, Chen, Arthur K., Rudy, Melissa A., Nasse, Jason S., Zeldich, Ella, Polanco, Taryn J., Abraham, Carmela R.
Publicado no PLoS One (2020)

Oxysterol-binding protein-1 (OSBP1) modulates processing and trafficking of the amyloid precursor protein

Por Zerbinatti, Celina V, Cordy, Joanna M, Chen, Ci-Di, Guillily, Maria, Suon, Sokreine, Ray, William J, Seabrook, Guy R, Abraham, Carmela R, Wolozin, Benjamin
Publicado em 2008

The Neuroprotective Effect of Klotho is Mediated via Regulation of Members of the Redox System

Por Zeldich, Ella, Chen, Ci-Di, Colvin, Teresa A., Bove-Fenderson, Erin A., Liang, Jennifer, Tucker Zhou, Tracey B., Harris, David A., Abraham, Carmela R.
Publicado em 2014

Identification of novel small molecules that elevate Klotho expression

Por King, Gwendalyn D., Chen, CiDi, Huang, Mickey M., Zeldich, Ella, Brazee, Patricia L., Schuman, Eli R., Robin, Maxime, Cuny, Gregory D., Glicksman, Marcie A., Abraham, Carmela R.
Publicado em 2012

Tau Phosphorylation is Impacted by Rare AKAP9 Mutations Associated with Alzheimer Disease in African Americans

Por Ikezu, Tsuneya, Chen, Cidi, DeLeo, Annina M., Zeldich, Ella, Fallin, M. Daniele, Kanaan, Nicholas M., Lunetta, Kathryn L., Abraham, Carmela R., Logue, Mark W., Farrer, Lindsay A.
Publicado no J Neuroimmune Pharmacol (2018)