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A method to specifically activate the Klotho promoter by using zinc finger proteins constructed from modular building blocks and from naturally engineered Egr1 transcription factor backbone

There is an unmet need for treatments for diseases associated with aging. The anti-aging, life-extending and cognition-enhancing protein Klotho is neuroprotective due to its anti-inflammatory, anti-oxidative and pro-myelinating effects. In addition, Klotho is also a tumor suppressor and has benefici...

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Publicat a:FASEB J
Autors principals: Chen, Ci-Di, Rudy, Melissa A., Zeldich, Ella, Abraham, Carmela R.
Format: Artigo
Idioma:Inglês
Publicat: 2020
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7302970/
https://ncbi.nlm.nih.gov/pubmed/32347987
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1096/fj.202000171R
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