Astroglial Expression of Human α(1)-Antichymotrypsin Enhances Alzheimer-like Pathology in Amyloid Protein Precursor Transgenic Mice

Proteases and their inhibitors play key roles in physiological and pathological processes. Cerebral amyloid plaques are a pathological hallmark of Alzheimer’s disease (AD). They contain amyloid-β (Aβ) peptides in tight association with the serine protease inhibitor α(1)-antichymotrypsin. 1,2 However...

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Bibliographic Details
Main Authors: Mucke, Lennart, Yu, Gui-Qiu, McConlogue, Lisa, Rockenstein, Edward M., Abraham, Carmela R., Masliah, Eliezer
Format: Artigo
Language:Inglês
Published: American Society for Investigative Pathology 2000
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC1885780/
https://ncbi.nlm.nih.gov/pubmed/11106573
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