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Elimination of the Class A Scavenger Receptor Does Not Affect Amyloid Plaque Formation or Neurodegeneration in Transgenic Mice Expressing Human Amyloid Protein Precursors
The class A scavenger receptor (SR) is expressed on reactive microglia surrounding cerebral amyloid plaques in Alzheimer’s disease (AD). Interactions between the SR and amyloid β peptides (Aβ) in microglial cultures elicit phagocytosis of Aβ aggregates and release of neurotoxins. To assess the role...
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| Main Authors: | , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Society for Investigative Pathology
1999
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1866996/ https://ncbi.nlm.nih.gov/pubmed/10550330 |
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