High-Level Neuronal Expression of Aβ(1–42) in Wild-Type Human Amyloid Protein Precursor Transgenic Mice: Synaptotoxicity without Plaque Formation

Amyloid plaques are a neuropathological hallmark of Alzheimer's disease (AD), but their relationship to neurodegeneration and dementia remains controversial. In contrast, there is a good correlation in AD between cognitive decline and loss of synaptophysin-immunoreactive (SYN-IR) presynaptic te...

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Publicado no:J Neurosci
Main Authors: Mucke, Lennart, Masliah, Eliezer, Yu, Gui-Qiu, Mallory, Margaret, Rockenstein, Edward M., Tatsuno, Gwen, Hu, Kang, Kholodenko, Dora, Johnson-Wood, Kelly, McConlogue, Lisa
Formato: Artigo
Idioma:Inglês
Publicado em: Society for Neuroscience 2000
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ARTICLE
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6772621/
https://ncbi.nlm.nih.gov/pubmed/10818140
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.20-11-04050.2000
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