Elimination of the Class A Scavenger Receptor Does Not Affect Amyloid Plaque Formation or Neurodegeneration in Transgenic Mice Expressing Human Amyloid Protein Precursors

The class A scavenger receptor (SR) is expressed on reactive microglia surrounding cerebral amyloid plaques in Alzheimer’s disease (AD). Interactions between the SR and amyloid β peptides (Aβ) in microglial cultures elicit phagocytosis of Aβ aggregates and release of neurotoxins. To assess the role...

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Autores principales: Huang, Frederick, Buttini, Manuel, Wyss-Coray, Tony, McConlogue, Lisa, Kodama, Tatsuhiko, Pitas, Robert E., Mucke, Lennart
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Investigative Pathology 1999
Materias:
Regular Articles
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC1866996/
https://ncbi.nlm.nih.gov/pubmed/10550330
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