Many Neuronal and Behavioral Impairments in Transgenic Mouse Models of Alzheimer's Disease Are Independent of Caspase Cleavage of the Amyloid Precursor Protein

Previous studies suggested that cleavage of the amyloid precursor protein (APP) at aspartate residue 664 by caspases may play a key role in the pathogenesis of Alzheimer's disease. Mutation of this site (D664A) prevents caspase cleavage and the generation of the C-terminal APP fragments C31 and...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Main Authors: Harris, Julie A., Devidze, Nino, Halabisky, Brian, Lo, Iris, Thwin, Myo T., Yu, Gui-Qiu, Bredesen, Dale E., Masliah, Eliezer, Mucke, Lennart
Formato: Artigo
Idioma:Inglês
Publicado em: Society for Neuroscience 2010
Assuntos:
Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3064502/
https://ncbi.nlm.nih.gov/pubmed/20053918
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.5341-09.2010
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados