Many Neuronal and Behavioral Impairments in Transgenic Mouse Models of Alzheimer's Disease Are Independent of Caspase Cleavage of the Amyloid Precursor Protein

Previous studies suggested that cleavage of the amyloid precursor protein (APP) at aspartate residue 664 by caspases may play a key role in the pathogenesis of Alzheimer's disease. Mutation of this site (D664A) prevents caspase cleavage and the generation of the C-terminal APP fragments C31 and...

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Autores principales: Harris, Julie A., Devidze, Nino, Halabisky, Brian, Lo, Iris, Thwin, Myo T., Yu, Gui-Qiu, Bredesen, Dale E., Masliah, Eliezer, Mucke, Lennart
Formato: Artigo
Lenguaje:Inglês
Publicado: Society for Neuroscience 2010
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Articles
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3064502/
https://ncbi.nlm.nih.gov/pubmed/20053918
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.5341-09.2010
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