Transsynaptic progression of amyloid-β-induced neuronal dysfunction within the entorhinal-hippocampal network

The entorhinal cortex (EC) is one of the earliest affected and most vulnerable brain regions in Alzheimer’s disease (AD), which is associated with amyloid-β (Aβ) accumulation in many brain areas. We show selective overexpression of mutant amyloid precursor protein (APP) predominantly in layer II/III...

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Hauptverfasser: Harris, Julie A., Devidze, Nino, Verret, Laure, Ho, Kaitlyn, Halabisky, Brian, Thwin, Myo T., Kim, Daniel, Hamto, Patricia, Lo, Iris, Yu, Gui-Qiu, Palop, Jorge J., Masliah, Eliezer, Mucke, Lennart
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2010
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3050043/
https://ncbi.nlm.nih.gov/pubmed/21040845
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neuron.2010.10.020
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