Human P301L-Mutant Tau Expression in Mouse Entorhinal-Hippocampal Network Causes Tau Aggregation and Presynaptic Pathology but No Cognitive Deficits

Accumulation of hyperphosphorylated tau in the entorhinal cortex (EC) is one of the earliest pathological hallmarks in patients with Alzheimer’s disease (AD). It can occur before significant Aβ deposition and appears to “spread” into anatomically connected brain regions. To determine whether this ea...

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Detalhes bibliográficos
Main Authors: Harris, Julie A., Koyama, Akihiko, Maeda, Sumihiro, Ho, Kaitlyn, Devidze, Nino, Dubal, Dena B., Yu, Gui-Qiu, Masliah, Eliezer, Mucke, Lennart
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2012
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3454317/
https://ncbi.nlm.nih.gov/pubmed/23029293
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0045881
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