Human P301L-Mutant Tau Expression in Mouse Entorhinal-Hippocampal Network Causes Tau Aggregation and Presynaptic Pathology but No Cognitive Deficits

Accumulation of hyperphosphorylated tau in the entorhinal cortex (EC) is one of the earliest pathological hallmarks in patients with Alzheimer’s disease (AD). It can occur before significant Aβ deposition and appears to “spread” into anatomically connected brain regions. To determine whether this ea...

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Detaylı Bibliyografya
Asıl Yazarlar: Harris, Julie A., Koyama, Akihiko, Maeda, Sumihiro, Ho, Kaitlyn, Devidze, Nino, Dubal, Dena B., Yu, Gui-Qiu, Masliah, Eliezer, Mucke, Lennart
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Public Library of Science 2012
Konular:
Research Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC3454317/
https://ncbi.nlm.nih.gov/pubmed/23029293
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0045881
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