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Promoter methylation and age-related downregulation of Klotho in rhesus monkey
While overall DNA methylation decreases with age, CpG-rich areas of the genome can become hypermethylated. Hypermethylation near transcription start sites typically decreases gene expression. Klotho (KL) is important in numerous age-associated pathways including insulin/IGF1 and Wnt signaling and na...
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| Main Authors: | , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
Springer Netherlands
2011
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3528360/ https://ncbi.nlm.nih.gov/pubmed/21922250 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s11357-011-9315-4 |
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