Opposing efficacy of group III mGlu receptor activators, LSP1-2111 and AMN082, in animal models of positive symptoms of schizophrenia

Por Wierońska, Joanna M., Stachowicz, Katarzyna, Acher, Francine, Lech, Tomasz, Pilc, Andrzej
Publicado em 2011

Molecular Determinants of Agonist Selectivity in Glutamate-Gated Chloride Channels Which Likely Explain the Agonist Selectivity of the Vertebrate Glycine and GABA(A)-ρ Receptors

Por Blarre, Thomas, Bertrand, Hugues-Olivier, Acher, Francine C., Kehoe, JacSue
Publicado em 2014

The heptahelical domain of GABA(B2) is activated directly by CGP7930, a positive allosteric modulator of the GABA(B) receptor

Por Binet, Virginie, Brajon, Carole, Le Corre, Laurent, Acher, Francine, Pin, Jean-Philippe, Prézeau, Laurent
Publicado em 2004

The antipsychotic-like effects of the mGlu group III orthosteric agonist, LSP1-2111, involves 5-HT(1A) signalling

Por Wierońska, Joanna M., Acher, Francine C., Sławińska, Anna, Gruca, Piotr, Łasoń-Tyburkiewicz, Magdalena, Papp, Mariusz, Pilc, Andrzej
Publicado em 2013

Closure of the Venus flytrap module of mGlu8 receptor and the activation process: Insights from mutations converting antagonists into agonists

Por Bessis, Anne-Sophie, Rondard, Philippe, Gaven, Florence, Brabet, Isabelle, Triballeau, Nicolas, Prézeau, Laurent, Acher, Francine, Pin, Jean-Philippe
Publicado em 2002

Involvement of GABA(B) Receptor Signaling in Antipsychotic-like Action of the Novel Orthosteric Agonist of the mGlu(4) Receptor, LSP4-2022

Por Woźniak, Monika, Acher, Francine, Marciniak, Marcin, Łasoń-Tyburkiewicz, Magdalena, Gruca, Piotr, Papp, Mariusz, Pilc, Andrzej, Wierońska, Joanna M.
Publicado no Curr Neuropharmacol (2016)

Asymmetric functioning of dimeric metabotropic glutamate receptors disclosed by positive allosteric modulators

Por Goudet, Cyril, Kniazeff, Julie, Hlavackova, Veronika, Malhaire, Fanny, Maurel, Damien, Acher, Francine, Blahos, Jaroslav, Prézeau, Laurent, Pin, Jean-Philippe
Publicado em 2005

Role of mGluR4 in acquisition of fear learning and memory

Por Davis, Matthew J., Iancu, Ovidiu D., Acher, Francine, Stewart, Blair M., Eiwaz, Massarra A., Duvoisin, Robert M., Raber, Jacob
Publicado em 2012

Heptahelical domain of metabotropic glutamate receptor 5 behaves like rhodopsin-like receptors

Por Goudet, Cyril, Gaven, Florence, Kniazeff, Julie, Vol, Claire, Liu, Jiangfeng, Cohen-Gonsaud, Martin, Acher, Francine, Prézeau, Laurent, Pin, Jean Philippe
Publicado em 2004

Phasic and Tonic mGlu7 Receptor Activity Modulates the Thalamocortical Network

Por Tassin, Valériane, Girard, Benoît, Chotte, Apolline, Fontanaud, Pierre, Rigault, Delphine, Kalinichev, Mikhail, Perroy, Julie, Acher, Francine, Fagni, Laurent, Bertaso, Federica
Publicado no Front Neural Circuits (2016)

Successful Prediction of Substrate-binding Pocket in SLC17 Transporter Sialin

Por Pietrancosta, Nicolas, Anne, Christine, Prescher, Horst, Ruivo, Raquel, Sagné, Corinne, Debacker, Cécile, Bertrand, Hugues-Olivier, Brossmer, Reinhard, Acher, Francine, Gasnier, Bruno
Publicado em 2012

Characteristics and composition of the vitamin K-dependent gamma-glutamyl carboxylase-binding domain on osteocalcin.

Por Houben, Roger J T J, Rijkers, Dirk T S, Stanley, Thomas B, Acher, Francine, Azerad, Robert, Käkönen, Sanna-Maria, Vermeer, Cees, Soute, Berry A M
Publicado em 2002

High potency olfactory receptor agonists discovered by virtual high-throughput screening: molecular probes for receptor structure and olfactory function

Por Triballeau, Nicolas, Van Name, Eric, Laslier, Guillaume, Cai, Diana, Paillard, Guillaume, Sorensen, Peter W., Hoffmann, Rémy, Bertrand, Hugues-Olivier, Ngai, John, Acher, Francine C.
Publicado em 2008

Qualification of LSP1-2111 as a Brain Penetrant Group III Metabotropic Glutamate Receptor Orthosteric Agonist

Por Cajina, Manuel, Nattini, Megan, Song, Dekun, Smagin, Gennady, Jørgensen, Erling B., Chandrasena, Gamini, Bundgaard, Christoffer, Toft, Dorthe Bach, Huang, Xinyan, Acher, Francine, Doller, Dario
Publicado em 2013

Identification of Positive Allosteric Modulators VU0155094 (ML397) and VU0422288 (ML396) Reveals New Insights into the Biology of Metabotropic Glutamate Receptor 7

Por Jalan-Sakrikar, Nidhi, Field, Julie R., Klar, Rebecca, Mattmann, Margrith E., Gregory, Karen J., Zamorano, Rocio, Engers, Darren W., Bollinger, Sean R., Weaver, C. David, Days, Emily L., Lewis, L. Michelle, Utley, Thomas J., Hurtado, Miguel, Rigault, Delphine, Acher, Francine, Walker, Adam G., Melancon, Bruce J., Wood, Michael R., Lindsley, Craig W., Conn, P. Jeffrey, Xiang, Zixiu, Hopkins, Corey R., Niswender, Colleen M.
Publicado no ACS Chem Neurosci (2014)