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181

A large deletion in GPR98 causes type IIC Usher syndrome in male and female patients of an Iranian family

A large deletion in GPR98 causes type IIC Usher syndrome in male and female patients of an Iranian family

Por Hilgert, Nele, Kahrizi, Kimia, Najmabadi, Hossein, Dieltjens, Nele, Bazazzadegan, Niloofar, Smith, Richard JH, Van Camp, Guy
Publicado no J Med Genet (2009)

“... recognised clinical phenotypes (types I, II and III; USH1, USH2 and USH3) are caused by mutations in nine...”
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182

A novel CGRP-neutralizing Spiegelmer attenuates neurogenic plasma protein extravasation

A novel CGRP-neutralizing Spiegelmer attenuates neurogenic plasma protein extravasation

Por Hoehlig, K, Johnson, K W, Pryazhnikov, E, Maasch, C, Clemens-Smith, A, Purschke, W G, Vauléon, S, Buchner, K, Jarosch, F, Khiroug, L, Vater, A, Klussmann, S
Publicado no Br J Pharmacol (2015)

“... in the pathology of migraine, and recent clinical trials suggest the inhibition of CGRP-mediated processes as a new...”
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183

Structural manipulation of aporphines via C10 nitrogenation leads to the identification of new 5-HT(7A)R ligands

Structural manipulation of aporphines via C10 nitrogenation leads to the identification of new 5-HT(7A)R ligands

Por Karki, Anupam, Namballa, Hari K., Alberts, Ian, Harding, Wayne W.
Publicado no Bioorg Med Chem (2020)

“... at 5-HT(1A)R, 5-HT(2A)R, 5-HT(6)R and 5-HT(7A)R. Three series of racemic aporphines were investigated...”
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184

A Potential Role for Shed Soluble Major Histocompatibility Class I Molecules as Modulators of Neurite Outgrowth

A Potential Role for Shed Soluble Major Histocompatibility Class I Molecules as Modulators of Neurite Outgrowth

Por Washburn, Lorraine R., Zekzer, Dan, Eitan, Shoshana, Lu, Yuxin, Dang, Hoa, Middleton, Blake, Evans, Christopher J., Tian, Jide, Kaufman, Daniel L.
Publicado em 2011

“...The neurobiological activities of classical major histocompatibility class I (MHCI) molecules...”
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185

Coexpression of human somatostatin receptor-2 (SSTR2) and SSTR3 modulates antiproliferative signaling and apoptosis

Coexpression of human somatostatin receptor-2 (SSTR2) and SSTR3 modulates antiproliferative signaling and apoptosis

Por War, Sajad A, Kumar, Ujendra
Publicado em 2012

“...BACKGROUND: Somatostatin (SST) via five G(i) coupled receptors namely SSTR1-5 is known to inhibit...”
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186

Lung injury combined with loss of regulatory T cells leads to de novo lung-restricted autoimmunity

Lung injury combined with loss of regulatory T cells leads to de novo lung-restricted autoimmunity

Por Chiu, Stephen, Fernandez, Ramiro, Subramanian, Vijay, Sun, Haiying, DeCamp, Malcolm M, Kreisel, Daniel, Perlman, Harris, Budinger, G.R. Scott, Mohanakumar, Thalachallour, Bharat, Ankit
Publicado no J Immunol (2016)

“...Over one-third of patients with chronic lung disease undergoing lung transplantation have pre...”
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187

Influence of asimadoline, a new κ-opioid receptor agonist, on tubular water absorption and vasopressin secretion in man

Influence of asimadoline, a new κ-opioid receptor agonist, on tubular water absorption and vasopressin secretion in man

Por Kramer, H J, Uhl, W, Ladstetter, B, Bäcker, A
Publicado em 2000

“... i.v. at a rate of 0.3 ml min(−1) kg(−1) during another 2 h urine collection. Blood was obtained hourly...”
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188

Refinement of Glucagon-like Peptide 1 Docking to Its Intact Receptor Using Mid-region Photolabile Probes and Molecular Modeling

Refinement of Glucagon-like Peptide 1 Docking to Its Intact Receptor Using Mid-region Photolabile Probes and Molecular Modeling

Por Miller, Laurence J., Chen, Quan, Lam, Polo C.-H., Pinon, Delia I., Sexton, Patrick M., Abagyan, Ruben, Dong, Maoqing
Publicado em 2011

“... probes incorporating a p-benzoyl-l-phenylalanine into positions 16 and 20 of GLP1(7–36). Both probes...”
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189

The CRTC1-SIK1 Pathway Regulates Entrainment of the Circadian Clock

The CRTC1-SIK1 Pathway Regulates Entrainment of the Circadian Clock

Por Jagannath, Aarti, Butler, Rachel, Godinho, Sofia I.H., Couch, Yvonne, Brown, Laurence A., Vasudevan, Sridhar R., Flanagan, Kevin C., Anthony, Daniel, Churchill, Grant C., Wood, Matthew J.A., Steiner, Guido, Ebeling, Martin, Hossbach, Markus, Wettstein, Joseph G., Duffield, Giles E., Gatti, Silvia, Hankins, Mark W., Foster, Russell G., Peirson, Stuart N.
Publicado em 2013

“..., and it remains unclear why entrainment to a new time zone takes several days. By analyzing the light-regulated...”
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190

Investigation on Quantitative Structure Activity Relationships and Pharmacophore Modeling of a Series of mGluR2 Antagonists

Investigation on Quantitative Structure Activity Relationships and Pharmacophore Modeling of a Series of mGluR2 Antagonists

Por Zhang, Meng-Qi, Zhang, Xiao-Le, Li, Yan, Fan, Wen-Jia, Wang, Yong-Hua, Hao, Ming, Zhang, Shu-Wei, Ai, Chun-Zhi
Publicado em 2011

“... relationship (3D-QSAR) studies of a series of 1,3-dihydrobenzo[ b][1,4]diazepin-2-one derivatives as mGluR2...”
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191

T-Cell Receptor/CD28 Engagement When Combined with Prostaglandin E(2) Treatment Leads to Potent Activation of Human T-Cell Leukemia Virus Type 1

T-Cell Receptor/CD28 Engagement When Combined with Prostaglandin E(2) Treatment Leads to Potent Activation of Human T-Cell Leukemia Virus Type 1

Por Dumais, Nancy, Paré, Marie-Ève, Mercier, Simon, Bounou, Salim, Marriot, Susan J., Barbeau, Benoit, Tremblay, Michel J.
Publicado em 2003

“... regarding the nature of extracellular stimuli that can transactivate the regulatory elements of HTLV-1 (i...”
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192

The Lactate Receptor HCAR1 Modulates Neuronal Network Activity through the Activation of G(α) and G(βγ) Subunits

The Lactate Receptor HCAR1 Modulates Neuronal Network Activity through the Activation of G(α) and G(βγ) Subunits

Por de Castro Abrantes, Haíssa, Briquet, Marc, Schmuziger, Céline, Restivo, Leonardo, Puyal, Julien, Rosenberg, Nadia, Rocher, Anne-Bérengère, Offermanns, Stefan, Chatton, Jean-Yves
Publicado no J Neurosci (2019)

“..., the basal activity was increased compared with WT. HCAR1 mediates its effect in neurons through a G(iα...”
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193

β‐adrenergic‐mediated dynamic augmentation of sarcolemmal Ca(V)1.2 clustering and co‐operativity in ventricular myocytes

β‐adrenergic‐mediated dynamic augmentation of sarcolemmal Ca(V)1.2 clustering and co‐operativity in ventricular myocytes

Por Ito, Danica W., Hannigan, Karen I., Ghosh, Debapriya, Xu, Bing, del Villar, Silvia G., Xiang, Yang K., Dickson, Eamonn J., Navedo, Manuel F., Dixon, Rose E.
Publicado no J Physiol (2019)

“... A signalling pathway leads to enhanced L‐type Ca(V)1.2 channel activity, resulting in increased Ca(2...”
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194

Selective Cannabinoid 2 Receptor Stimulation Reduces Tubular Epithelial Cell Damage after Renal Ischemia-Reperfusion Injury

Selective Cannabinoid 2 Receptor Stimulation Reduces Tubular Epithelial Cell Damage after Renal Ischemia-Reperfusion Injury

Por Pressly, Jeffrey D., Mustafa, Suni M., Adibi, Ammaar H., Alghamdi, Sahar, Pandey, Pankaj, Roy, Kuldeep K., Doerksen, Robert J., Moore, Bob M., Park, Frank
Publicado no J Pharmacol Exp Ther (2018)

“...Ischemia-reperfusion injury (IRI) is a common cause of acute kidney injury (AKI), which...”
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195

New putative insights into neprilysin (NEP)-dependent pharmacotherapeutic role of roflumilast in treating COVID-19

New putative insights into neprilysin (NEP)-dependent pharmacotherapeutic role of roflumilast in treating COVID-19

Por El Tabaa, Manar Mohammed, El Tabaa, Maram Mohammed
Publicado no Eur J Pharmacol (2020)

“... block the neutrophilic component of COVID-19. One of the effective therapeutic approaches investigated...”
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196

Rare, functional, somatic variants in gene families linked to cancer genes: GPCR signaling as a paradigm

Rare, functional, somatic variants in gene families linked to cancer genes: GPCR signaling as a paradigm

Por Raimondi, Francesco, Inoue, Asuka, Kadji, Francois M. N., Shuai, Ni, Gonzalez, Juan-Carlos, Singh, Gurdeep, de la Vega, Alicia Alonso, Sotillo, Rocio, Fischer, Bernd, Aoki, Junken, Gutkind, J. Silvio, Russell, Robert B.
Publicado no Oncogene (2019)

“... as significant in any one-gene-at-a-time analysis. Here, we looked for mutated, functional sequence positions...”
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197

Thermodynamics and Docking of Agonists to the β(2)-Adrenoceptor Determined Using [(3)H](R,R′)-4-Methoxyfenoterol as the Marker Ligand

Thermodynamics and Docking of Agonists to the β(2)-Adrenoceptor Determined Using [(3)H](R,R′)-4-Methoxyfenoterol as the Marker Ligand

Por Toll, Lawrence, Pajak, Karolina, Plazinska, Anita, Jozwiak, Krzysztof, Jimenez, Lucita, Kozocas, Joseph A., Tanga, Mary J., Bupp, James E., Wainer, Irving W.
Publicado em 2012

“...)-adrenergic receptor, we developed a new agonist radioligand for binding assays. [(3)H](R,R′)-methoxyfenoterol...”
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198

Epigenetic modifications in frontal cortex from Alzheimer's disease and bipolar disorder patients

Epigenetic modifications in frontal cortex from Alzheimer's disease and bipolar disorder patients

Por Rao, J S, Keleshian, V L, Klein, S, Rapoport, S I
Publicado em 2012

“..., and histone H3 phosphorylation. These changes were associated with hypo- and hypermethylation of CpG islands...”
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199

Molecular Mechanisms of Class B GPCR Activation: Insights from Adrenomedullin Receptors

Molecular Mechanisms of Class B GPCR Activation: Insights from Adrenomedullin Receptors

Por Garelja, Michael L., Au, Maggie, Brimble, Margaret A., Gingell, Joseph J., Hendrikse, Erica R., Lovell, Annie, Prodan, Nicole, Sexton, Patrick M., Siow, Andrew, Walker, Christopher S., Watkins, Harriet A., Williams, Geoffrey M., Wootten, Denise, Yang, Sung H., Harris, Paul W. R., Hay, Debbie L.
Publicado no ACS Pharmacol Transl Sci (2020)

“... (CLR), in complex with one of three receptor activity-modifying proteins (RAMPs). The C-terminus of AM...”
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200

Mechanisms of Action of Autophagy Modulators Dissected by Quantitative Systems Pharmacology Analysis

Mechanisms of Action of Autophagy Modulators Dissected by Quantitative Systems Pharmacology Analysis

Por Shi, Qingya, Pei, Fen, Silverman, Gary A., Pak, Stephen C., Perlmutter, David H., Liu, Bing, Bahar, Ivet
Publicado no Int J Mol Sci (2020)

“... proteins (~30% of modulators). They are mediated by three layers of regulation: (i) pathways involving core...”
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