Rare, functional, somatic variants in gene families linked to cancer genes: GPCR signaling as a paradigm

Oncodriver genes are usually identified when mutations recur in multiple tumours. Different drivers often converge in the activation or repression of key cancer-relevant pathways. However, as many pathways contain multiple members of the same gene family, individual mutations might be overlooked, as...

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Detalhes bibliográficos
Publicado no:Oncogene
Main Authors: Raimondi, Francesco, Inoue, Asuka, Kadji, Francois M. N., Shuai, Ni, Gonzalez, Juan-Carlos, Singh, Gurdeep, de la Vega, Alicia Alonso, Sotillo, Rocio, Fischer, Bernd, Aoki, Junken, Gutkind, J. Silvio, Russell, Robert B.
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2019
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6756116/
https://ncbi.nlm.nih.gov/pubmed/31337866
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41388-019-0895-2
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