Illuminating G-Protein-Coupling Selectivity of GPCRs

Heterotrimetic G proteins consist of four subfamilies (G(S), G(i/O), G(q/11), and G(12/13)) that mediate signaling via G-protein-coupled receptors (GPCRs), principally by receptors binding Gα C termini. G-protein-coupling profiles govern GPCR-induced cellular responses, yet receptor sequence selecti...

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Publicado en:Cell
Main Authors: Inoue, Asuka, Raimondi, Francesco, Kadji, Francois Marie Ngako, Singh, Gurdeep, Kishi, Takayuki, Uwamizu, Akiharu, Ono, Yuki, Shinjo, Yuji, Ishida, Satoru, Arang, Nadia, Kawakami, Kouki, Gutkind, J. Silvio, Aoki, Junken, Russell, Robert B.
Formato: Artigo
Idioma:Inglês
Publicado: 2019
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC6773469/
https://ncbi.nlm.nih.gov/pubmed/31160049
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2019.04.044
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