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Crystal structure of human endothelin ET(B) receptor in complex with peptide inverse agonist IRL2500

Endothelin receptors (ET(A) and ET(B)) are G-protein-coupled receptors activated by endothelin-1 and are involved in blood pressure regulation. IRL2500 is a peptide-mimetic of the C-terminal tripeptide of endothelin-1, and has been characterized as a potent ET(B)-selective antagonist, which has prev...

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Bibliografske podrobnosti
izdano v:Commun Biol
Main Authors: Nagiri, Chisae, Shihoya, Wataru, Inoue, Asuka, Kadji, Francois Marie Ngako, Aoki, Junken, Nureki, Osamu
Format: Artigo
Jezik:Inglês
Izdano: Nature Publishing Group UK 2019
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC6588608/
https://ncbi.nlm.nih.gov/pubmed/31263780
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s42003-019-0482-7
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