Crystal structures of human ET(B) receptor provide mechanistic insight into receptor activation and partial activation

Endothelin receptors (ET(A) and ET(B)) are class A GPCRs activated by vasoactive peptide endothelins, and are involved in blood pressure regulation. ET(B)-selective signalling induces vasorelaxation, and thus selective ET(B) agonists are expected to be utilized for improved anti-tumour drug delivery...

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Bibliografiska uppgifter
I publikationen:Nat Commun
Huvudupphovsmän: Shihoya, Wataru, Izume, Tamaki, Inoue, Asuka, Yamashita, Keitaro, Kadji, Francois Marie Ngako, Hirata, Kunio, Aoki, Junken, Nishizawa, Tomohiro, Nureki, Osamu
Materialtyp: Artigo
Språk:Inglês
Publicerad: Nature Publishing Group UK 2018
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Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC6226434/
https://ncbi.nlm.nih.gov/pubmed/30413709
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-018-07094-0
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