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Crystal structures of human ET(B) receptor provide mechanistic insight into receptor activation and partial activation
Endothelin receptors (ET(A) and ET(B)) are class A GPCRs activated by vasoactive peptide endothelins, and are involved in blood pressure regulation. ET(B)-selective signalling induces vasorelaxation, and thus selective ET(B) agonists are expected to be utilized for improved anti-tumour drug delivery...
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| Publicado no: | Nat Commun |
|---|---|
| Main Authors: | , , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Nature Publishing Group UK
2018
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6226434/ https://ncbi.nlm.nih.gov/pubmed/30413709 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-018-07094-0 |
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