Cryo-EM reveals mechanistic insights into lipid-facilitated polyamine export by human ATP13A2

The cytoplasmic polyamine maintains cellular homeostasis by chelating toxic metal cations, regulating transcriptional activity, and protecting DNA. ATP13A2 was identified as a lysosomal polyamine exporter responsible for polyamine release into the cytosol, and its dysfunction is associated with Alzh...

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Veröffentlicht in:Mol Cell
Hauptverfasser: Tomita, Atsuhiro, Daiho, Takashi, Kusakizako, Tsukasa, Yamashita, Keitaro, Ogasawara, Satoshi, Murata, Takeshi, Nishizawa, Tomohiro, Nureki, Osamu
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2021
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7612442/
https://ncbi.nlm.nih.gov/pubmed/34798056
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2021.11.001
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