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Cryo-EM reveals mechanistic insights into lipid-facilitated polyamine export by human ATP13A2
The cytoplasmic polyamine maintains cellular homeostasis by chelating toxic metal cations, regulating transcriptional activity, and protecting DNA. ATP13A2 was identified as a lysosomal polyamine exporter responsible for polyamine release into the cytosol, and its dysfunction is associated with Alzh...
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| Publicado en: | Mol Cell |
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| Autores principales: | , , , , , , , |
| Formato: | Artigo |
| Lenguaje: | Inglês |
| Publicado: |
2021
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| Materias: | |
| Acceso en línea: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7612442/ https://ncbi.nlm.nih.gov/pubmed/34798056 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2021.11.001 |
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