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New paradigms in GPCR drug discovery

G protein-coupled receptors (GPCRs) remain a major domain of pharmaceutical discovery. The discovery of GPCR lead compounds and their optimization are now structure-based, thanks to advances in X-ray crystallography, molecular modeling, protein engineering and biophysical techniques. In silico scree...

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書目詳細資料
發表在:Biochem Pharmacol
主要作者: Jacobson, Kenneth A.
格式: Artigo
語言:Inglês
出版: 2015
主題:
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC4967540/
https://ncbi.nlm.nih.gov/pubmed/26265138
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bcp.2015.08.085
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