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New paradigms in GPCR drug discovery
G protein-coupled receptors (GPCRs) remain a major domain of pharmaceutical discovery. The discovery of GPCR lead compounds and their optimization are now structure-based, thanks to advances in X-ray crystallography, molecular modeling, protein engineering and biophysical techniques. In silico scree...
Gardado en:
| Publicado en: | Biochem Pharmacol |
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| Autor Principal: | |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
2015
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4967540/ https://ncbi.nlm.nih.gov/pubmed/26265138 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bcp.2015.08.085 |
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