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Refinement of Glucagon-like Peptide 1 Docking to Its Intact Receptor Using Mid-region Photolabile Probes and Molecular Modeling

The glucagon-like peptide 1 (GLP1) receptor is an important drug target within the B family of G protein-coupled receptors. Its natural agonist ligand, GLP1, has incretin-like actions and the receptor is a recognized target for management of type 2 diabetes mellitus. Despite recent solution of the s...

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Main Authors: Miller, Laurence J., Chen, Quan, Lam, Polo C.-H., Pinon, Delia I., Sexton, Patrick M., Abagyan, Ruben, Dong, Maoqing
格式: Artigo
語言:Inglês
出版: American Society for Biochemistry and Molecular Biology 2011
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC3091199/
https://ncbi.nlm.nih.gov/pubmed/21454562
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.217901
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