Molecular Basis of Secretin Docking to Its Intact Receptor Using Multiple Photolabile Probes Distributed throughout the Pharmacophore

The molecular basis of ligand binding and activation of family B G protein-coupled receptors is not yet clear due to the lack of insight into the structure of intact receptors. Although NMR and crystal structures of amino-terminal domains of several family members support consistency in general stru...

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Detalhes bibliográficos
Main Authors: Dong, Maoqing, Lam, Polo C.-H., Pinon, Delia I., Hosohata, Keiko, Orry, Andrew, Sexton, Patrick M., Abagyan, Ruben, Miller, Laurence J.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2011
Assuntos:
Protein Structure and Folding
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3129170/
https://ncbi.nlm.nih.gov/pubmed/21566140
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.245969
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