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Elucidation of the Molecular Basis of Cholecystokinin Peptide Docking to Its Receptor Using Site-Specific Intrinsic Photoaffinity Labeling and Molecular Modeling

G protein-coupled receptors represent the largest family of receptors and the major target of current drug development efforts. Understanding of the mechanisms of ligand binding and activation of these receptors remains limited, despite recent advances in structural determination of family members....

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Autori principali: Dong, Maoqing, Lam, Polo C.-H., Pino, Delia I., Abagyan, Ruben, Miller, Laurence J.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2009
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3443625/
https://ncbi.nlm.nih.gov/pubmed/19441839
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi9004705
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